Changes in fluidity and composition of erythrocyte membranes and in composition of plasma lipids in Type I diabetes
- 1 January 1986
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 62 (1) , 111-116
- https://doi.org/10.1111/j.1365-2141.1986.tb02906.x
Abstract
Changes in the fluidity and composition of human erythrocyte membranes and in the compostion of plasma in Type I (insuln-dependent) diabetes were investigated. The increased microviscosity of diabetic erythrocyte membranes provide unambiguous proof of the structural deterioration of erythrocyte membranes in diabetes. It seems most likely that enhancement of the membrane cholesterol/phospholipid ratio is the main reason for decreased membrane fluidity in diabetes. A distinct correlation between membrane cholesterol/phospholipid ratio, plasma cholesterol content and membrane fluidity was found. Composition and structural changes in erythrocyte membranes and compositional changes in plasma lipids may contribute to the development of diabetic complications in diabetes.This publication has 24 references indexed in Scilit:
- Dietary effects on very low-density lipoproteins in type 2 (non-insulin-dependent) diabetes mellitusDiabetologia, 1982
- Low-frequency motion in membranes. The effect of cholesterol and proteinsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1982
- Red blood cell [14C]cholesterol exchange and plasma cholesterol esterifying activity of normal and sickle cell bloodBiochimica et Biophysica Acta (BBA) - Biomembranes, 1982
- Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurementsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1981
- Increased glycosylation of serum albumin in diabetes mellitusDiabetes, 1980
- Fluidity parameters of lipid regions determined by fluorescence polarizationBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1978
- The exchangeability of human erythrocyte membrane cholesterolJournal of Supramolecular Structure, 1978
- Metabolic approaches to studies on diabetic microangiopathyDiabetes, 1977
- Lateral diffusion in the hydrophobic region of membranes: use of pyrene excimers as optical probesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1974
- An Analysis of Lipoproteins, Bile Acids, and Red Cell Membranes Associated with Target Cells and Spur Cells in Patients with Liver DiseaseJournal of Clinical Investigation, 1972