ACUTE TOXIC EFFECTS OF CHAETOGLOBOSIN-A, A NEW CYTOCHALASAN COMPOUND PRODUCED BY CHAETOMIUM-GLOBOSUM, ON MICE AND RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 48  (2) , 105-110
Abstract
A new cytochalasan compound, chaetoglobosin A produced by C. globosum, was studied for its toxicity to animals. By s.c. injection, 2 mg/kg body wt of chaetoglobosin A killed young Wistar rats, and in the mouse of DDD strain, LD50 values of chaetoglobosin A were about 6.5 and 17.8 mg/kg for males and females, respectively. By oral administration, 400 mg/kg of chaetoglobosin A had a slight adverse effect on mice and rats. Pathological examination of the mice, injected s.c. with 5 mg/kg of the toxin, revealed marked edema at the injection site which appeared several hours after injection and subsided in a week. In other tissues necrosis of the thymus and spleen and degeneration of the spermatocytes in the testicles were noticeable. With characteristic cytotoxic effects like cytochalasin B, chaetoglobosin A is an interesting mycotoxin.

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