A C5-Derived Macrophage Chemotactic Factor from DNP-Ascaris Extract-Induced Skin Lesion in Guinea Pigs
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 70 (4) , 361-367
- https://doi.org/10.1159/000233348
Abstract
In complement-depleted condition induced by cobra venom factor (CoF), tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of Infraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.Keywords
This publication has 1 reference indexed in Scilit:
- Chemical Coupling of Proteins to AgaroseNature, 1967