Effect of Thyroxine, Thyrotrophic and Somatotropic Hormones on Skin of Dwarf Mice.

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Abstract
Dwarf mice and their normal siblings were given thyroxine, thyrotropic and somatotropic hormones or physiological saline intraperitoneally. In the skin the mast cells were counted and concentration of hexosamine and hydroxyproline were determined. The number of mast cells did not show any significant variation in the different groups. Concentration of hexosamine in the skin of thyrotropin-treated dwarf mice was significantly higher than concentration in control dwarf mice. Hexosamine values in the group of thyroxine-treated mice were higher than in the group of control mice. Hydroxyproline content was significantly higher in the skin of thyrotropin-treated dwarf mice than in thyroxine-treated dwarf mice. These results suggest that thyrotropic hormone stimulates and thyroxine inhibits formation of collagen fibrils.