The neurotrophic analogue of ACTH(4–9), Org 2766, protects against experimental allergic neuritis
- 1 October 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Brain
- Vol. 116 (5) , 1059-1075
- https://doi.org/10.1093/brain/116.5.1059
Abstract
Demyelinating diseases such as multiple sclerosis or the Guillain-Barré syndrome originate from an autoimmune response resulting in the degradation of myelin and impaired neuronal function. Prophylactic administration of the neurotrophic peptide, H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (an ACTH(4–9) analogue), to rats with experimental allergic neuritis, a model for the Guillain-Barré syndrome, markedly suppresses the clinical symptoms, protects against loss of motor coordination and prevents the degeneration of myelinated axons in the affected peripheral nerve. Therefore, this peptide may provide a new approach to the therapy of peripheral demyelinating polyneuropathies.Keywords
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