Enantiospecific Synthesis of Optically Pure Propargylic Alcohols
- 1 January 1990
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1990 (10) , 591-593
- https://doi.org/10.1055/s-1990-21176
Abstract
Highly practical and enantiospecific method for the synthesis of optically pure propargylic alcohols [(S)-1-alkyn-3-ols] 1a-d from (-)-2-deoxy-D-ribose is described. The key reaction is the base-induced deprotonation-elimination reaction of 1-chloro-2,3-isopropylidenedioxyalkanes 4a-d and 8 with lithium diisopropylamide.Keywords
This publication has 0 references indexed in Scilit: