Enzymatic Modification of Aminoglycoside Antibiotics: a New 6′- N -Acetylating Enzyme from a Pseudomonas aeruginosa Isolate
- 1 June 1976
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 9 (6) , 945-950
- https://doi.org/10.1128/aac.9.6.945
Abstract
We describe an aminoglycoside 6′-N-acetyltransferase, isolated from Pseudomonas aeruginosa, that exhibits a novel substrate profile characterized by markedly reduced activity towards butirosin and amikacin.Keywords
This publication has 8 references indexed in Scilit:
- R Factor-Mediated Aminoglycoside Antibiotic Resistance in Pseudomonas aeruginosa : a New Aminoglycoside 6′- N -AcetyltransferaseAntimicrobial Agents and Chemotherapy, 1975
- [48] Aminoglycoside-modifying enzymesPublished by Elsevier ,1975
- Transferrable Resistance to Tobramycin in Klebsiella pneumoniae and Enterobacter cloacae Associated with Enzymatic Acetylation of TobramycinAntimicrobial Agents and Chemotherapy, 1974
- La résistance aux aminosides provoquée par une isoenzyme la kanamycine acétyltransféraseBiochimie, 1974
- Structure of sisomicin, a novel unsaturated aminocyclitol antibiotic from Micromonospora inyoensisThe Journal of Organic Chemistry, 1974
- Utilization of Carbon and Nitrogen Sources by Streptomyces kanamyceticus for Kanamycin ProductionAntimicrobial Agents and Chemotherapy, 1973
- Enzymic acetylation of aminoglycoside antibiotics by Excherichia coli carrying an R factorBiochemistry, 1971
- Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.1967