Synthesis of Optically Active 4-Alkoxycarbonyl-β-lactams from L-Aspartic Acid
- 1 March 1994
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 24 (6) , 745-753
- https://doi.org/10.1080/00397919408011295
Abstract
Cyclization of L-aspartic acid to (S)-4-benzyloxycarbonyl-2-azetidinone followed by transesterification of this compound in the presence of titanium (IV) tetrabutoxide proved to be an exceedingly efficient method of general application for the preparation of (S)-4-alkoxycarbonyl-β-lactams.Keywords
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