TRIAL OF INTRA-ARTICULAR ORGOTEIN, A SUPEROXIDE-DISMUTASE, IN EXPERIMENTALLY-INDUCED OSTEO-ARTHRITIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 7  (1) , 24-29
Abstract
Intraarticular [i.a.] injections of orgotein [OT], a metalloprotein with superoxide dismutase activity, did not ameliorate experimentally-induced osteoarthritis in the rabbit. Reduction of sulfate incorporation by cartilage of operated osteoarthritic knees with injection of saline-sucrose [S-S] placebo and OT in S-S vehicle was observed. Repeated i.a. injections of both OT in a S-S vehicle, and S-S placebo administered separately induced a severe synovitis in both osteoarthritic and normal knees.