The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse
Open Access
- 1 October 2009
- Vol. 31 (4) , 621-631
- https://doi.org/10.1016/j.immuni.2009.08.024
Abstract
No abstract availableKeywords
This publication has 38 references indexed in Scilit:
- T cell antigen receptor signaling and immunological synapse stability require myosin IIANature Immunology, 2009
- The Mitogen-Activated Protein Kinase Scaffold KSR1 Is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological SynapseMolecular and Cellular Biology, 2009
- JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicityProceedings of the National Academy of Sciences, 2008
- Recruitment of dynein to the Jurkat immunological synapseProceedings of the National Academy of Sciences, 2006
- CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cellsProceedings of the National Academy of Sciences, 2006
- T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation ClusterImmunity, 2006
- Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASPMolecular and Cellular Biology, 2004
- TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathwaysNature Immunology, 2003
- The Immunological Synapse: A Molecular Machine Controlling T Cell ActivationScience, 1999
- T cell receptor antagonist peptides induce positive selectionCell, 1994