Effects of Sucralfate vs Antacids on Gastric Pathogens

Open Access

1 March 1998

journal article
clinical trial
Published by American Medical Association (AMA) in Archives of Surgery

Vol. 133 (3) , 251-257
https://doi.org/10.1001/archsurg.133.3.251

Abstract

STRESS ULCER prophylaxis with agents that affect gastric acidity became standard therapy for physiologically stressed patients after controlled clinical trials demonstrated a reduction in the incidence of gastrointestinal tract bleeding when gastric pH is maintained above 4.0.¹^-3 Prevention of upper gastrointestinal tract bleeding during stress also has been accomplished with the surface-active agent sucralfate, with an efficacy similar to that of acid reduction, in unblinded clinical trials.⁴^-6

Keywords

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