The β Cell Population in Type 1 Diabetes

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Abstract
Type 1 diabetes is often considered as a disease where more than 90% of the β cells have been destroyed at clinical onset and where β cell antigen-driven autoimmune reactivities progressively destroy remaining β cells as well as newly formed or implanted β cells. This view will be evaluated in light of histological observations in the pancreas of type 1 diabetic patients and of antibody-positive non-diabetic organ donors.

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