EFFECT OF ACETAZOLAMIDE ON MOVEMENTS OF ANIONS INTO POSTERIOR CHAMBER OF DOG EYE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 196  (2) , 510-516
Abstract
The rate of entry of HCO3- and Cl- into the posterior chamber of the dog, a species that has both HCO3- and Cl- concentrations in excess of plasma in this chamber, was measured in order to clarify the mechanisms involved in the production of aqueous humor. Four animals were given H14CO3- and 36Cl- i.v. 1st in a control series and then after pretreatment with acetazolamide, (50 mg/kg), a carbonic anhydrase inhibitor. Samples were taken from arterial blood and the posterior chamber. Acetazolamide did not affect Cl- entry into the posterior chamber, but HCO3- entry was decreased about 50%. In this species HCO3- is the key anion for the decrease of aqueous humor production caused by the administration of acetazolamide.