Prostacyclin acts in rat gastric (fundic) mucosa via the intracellular ‘second messenger system’
- 1 October 1985
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 17 (1) , 46-47
- https://doi.org/10.1007/bf01966680
Abstract
Using a specific radioimmunoassay technique it seems that Prostacyclin (PG-I2) has a strong effect on the cyclic nucleotide content of the rat gastric (fundic) mucosa. 1 min after an intragastric application of 100 μg/kg PG-I2 the cAMP-content and in the 5th min the cGMP-content showed a highly significant decrease. It seems that the basic mechanism of action of PG-I2 is a typical ‘hit and run’ effect, acting on the intracellular ‘second messenger system’.This publication has 4 references indexed in Scilit:
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- Actinomycin inhibits gastric mucosal protection by prostacyclin in ratsProstaglandins, 1981
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951