Effects of p-chlorophenylalanine on rabbit taste receptor cells.
- 1 January 1982
- journal article
- research article
- Published by International Society of Histology & Cytology in Archivum histologicum japonicum
- Vol. 45 (4) , 365-373
- https://doi.org/10.1679/aohc.45.365
Abstract
By administration of p-chlorophenylalanine (PCPA), a synthetic inhibitor of 5-hydroxytryptamine (5-HT), to rabbits, granular vesicles in the taste receptor cells remarkably decreased their contents. The recovery of this core substance depletion occurred in specimens killed on the 15th day after injection of the drug and in animals injected with 5-hydroxytryptophan (5-HTP) after treatment with PCPA. EM observation suggests that granular vesicles in the receptor cells are 5-HT storing particles and favors the view based on recent fluorescence histochemistry which indicates the presence of a biogenic monoamine, presumably 5-HT in rabbit foliate taste bud cells.This publication has 1 reference indexed in Scilit:
- THE DISTRIBUTION OF 5‐HYDROXYTRYPTAMINE AND ADENOSINETRIPHOSPHATE IN CYTOPLASMIC PARTICLES OF THE DOG'S SMALL INTESTINEBritish Journal of Pharmacology and Chemotherapy, 1960