EFFECTS OF ANTIDEPRESSANT DRUGS ON NORADRENALINE ACCUMULATION AND CONTRACTILE RESPONSES IN THE RAT ANOCOCCYGEUS MUSCLE
Open Access
- 1 March 1977
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 59 (3) , 403-409
- https://doi.org/10.1111/j.1476-5381.1977.tb08393.x
Abstract
1 The effect of a series of antidepressant drugs on noradrenaline accumulation was studied in the isolated anococcygeus muscle of the rat. 2 The most potent inhibitors of noradrenaline accumulation were nortriptyline, desipramine and protriptyline. Opipramol, trimipramine and iprindole were active only in high concentrations. 3 Contractions of the anococcygeus muscle produced by noradrenaline were strongly potentiated by nortriptyline, desipramine and protriptyline. Other uptake inhibitors were less active in potentiating the noradrenaline response. 4 Nortriptyline, in concentrations that potentiated the action of noradrenaline, reduced or abolished the response to tyramine.Keywords
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