REGULATION OF LEISHMANIA POPULATIONS WITHIN THE HOST .4. PARASITE AND HOST-CELL KINETICS STUDIED BY RADIOISOTOPE LABELING
- 1 January 1979
- journal article
- research article
- Vol. 36 (2) , 171-179
Abstract
3H-thymidine pulse labeling followed by autoradiography was used to analyze the kinetics of L. donovani infections within the mouse host. Resistant strains of mice show much lower parasite proliferation rates than do susceptible strains. In chronic infections the rate is reduced. Parasitized mononuclear phagocytes may undergo mitosis. No evidence for selective destruction of parasitized cells in chronic infections was found by labeling methods. It is possible to get parasite labeling in vitro immediately after biopsy to levels comparable to those seen in vivo.This publication has 3 references indexed in Scilit:
- REGULATION OF LEISHMANIA POPULATIONS WITHIN HOST .2. GENETIC-CONTROL OF ACUTE SUSCEPTIBILITY OF MICE TO LEISHMANIA-DONOVANI INFECTION1977
- REGULATION OF LEISHMANIA POPULATIONS WITHIN HOST .1. VARIABLE COURSE OF LEISHMANIA-DONOVANI INFECTIONS IN MICE1977
- Antigenic variation in clones ofTrypanosoma bruceiPathogens and Global Health, 1965