A Neuroendocrine Marker in Tissues of the Immune System
- 4 October 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 230 (4721) , 89-90
- https://doi.org/10.1126/science.3898368
Abstract
Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin-immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.This publication has 12 references indexed in Scilit:
- Neurons and neuroendocrine cells contain chromogranin: detection of the molecule in normal bovine tissues by immunochemical and immunohistochemical methods.Journal of Histochemistry & Cytochemistry, 1985
- Chromogranin immunoreactivity in the central nervous system. Immunochemical characterisation, distribution and relationship to catecholamine and enkephalin pathwaysBrain Research Reviews, 1984
- Thymosins: hormones of the thymus glandTrends in Pharmacological Sciences, 1984
- DETECTION OF CHROMOGRANIN IN NEUROENDOCRINE CELLS WITH A MONOCLONAL-ANTIBODY1984
- Chromogranin A: Immunohistology reveals its universal occurrence in normal polypeptide hormone producing endocrine glandsLife Sciences, 1983
- Current views on the paraneurone conceptTrends in Neurosciences, 1979
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970