Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis
- 1 April 2005
- journal article
- review article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 16 (6) , 527-531
- https://doi.org/10.1097/00001756-200504250-00001
Abstract
Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and amyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies.Keywords
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