Effect of Age and Route of Administration on LD50 of Lithium Chloride in the Rat *

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Abstract
Male inbred rats were used to determine the lethal dose of lithium chloride. The rats were 3 wk, 6 wk, 3 mo. and 6 mo. old, and lithium chloride was given i.p., s.c. and orally. In relation to age, LD50 was significantly higher in rats of 6 wk after oral administration than LD50 in rats of 3 and 6 mo. No differences were found following i.p. and s.c. administration. In relation to route of administration, LD50 was significantly higher in rats of 3 and 6 wk after oral administration than LD50 after i.p. and s.c. administration. This difference was not found in rats of 3 and 6 mo. Age and route of administration are of significance for LD50 of lithium chloride in the rat.

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