Light-scattering changes accompanying spreading depression in isolated retina.

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Abstract
The spreading depression in the isolated retina is accompanied by a reproducible sequence of changes of intensity of the light scattered within the tissue. The sequence of these optical changes has a duration of 15 - 30 min. The magnitude of the scattered light intensity changes may amount to more than 30% of the base line intensity and is largest in the inner plexiform layer. The base line intensity varies directly with the osmolarity of the solution in which the retina is maintained. In hyper-osmolar solutions, during spreading depression, the sequence of changes presents a sharp initial intensity fall, lasting only a few seconds, which does not appear in hypo-osmolar solutions. The course of the light scattering changes may be influenced by temperature and chemical agents.

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