PROSTAGLANDIN D2 IS THE PREVAILING PROSTAGLANDIN IN THE ACUTE INFLAMMATORY EXUDATE OF URATE ARTHRITIS IN THE CHICKEN
Open Access
- 1 March 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 65 (3) , 357-359
- https://doi.org/10.1111/j.1476-5381.1979.tb07837.x
Abstract
An acute inflammation was elicited in intertarsal joints of chicken by injection of urate crystals. Inflammatory exudates recovered at different times were assayed for prostaglandin D2(PGD2) E2 and F2α and thromboxane B2 content by specific radioimmunoassays. We found that PGD2 was the prevailing prostaglandin reaching concentrations up to 10 times in excess of PGE2. This finding was confirmed by gas chromatography‐mass spectrometry. It is concluded that PGD2 should be considered as a possible mediator of acute inflammation.Keywords
This publication has 15 references indexed in Scilit:
- Radioimmunological determination of prostaglandin D2 synthesis in human thrombocytesCellular and Molecular Life Sciences, 1978
- Effect of imidazole on prostaglandin and thromboxane accumulation in urate arthritisEuropean Journal of Pharmacology, 1978
- Role of prostaglandin endoperoxide PGG2 in inflammatory processesNature, 1977
- ISomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albuminBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKINBritish Journal of Pharmacology, 1976
- Leukocytes and prostaglandins in acute inflammationCellular and Molecular Life Sciences, 1974
- Prostaglandin D2 inhibits the aggregation of human plateletsThrombosis Research, 1974
- The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammationInflammation Research, 1974
- Isolation and properties of intermediates in prostaglandin biosynthesisBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1973
- Relationship between chemical structure and plateletaggregation activity of prostaglandinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969