A Study on Endotoxin-Induced Disseminated Intravascular Coagulation (DIC) in the Dog

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Abstract
In order to make a DIC model, 15 normal dogs were injected with Escherichia coli endotoxin, or lipopolysaccharide, via a venous catheter for 10 hours. hours. The platelet count decreased drastically in dogs after endotoxin injection. It was maintained at a low level during the experiment. The fibrinogen amount also decreased after the injection. It was about half of the pre-injection amount 6 to 7 hours after the infusion. PT and APTT prolonged after the injection. FDPs increased in all the dogs 2 hours after the injection. They were more than 40μg/ml in 13 dogs. Autopsy revealed severe hemorrhage in the intestine and congestion in the liver, spleen and kidney in most cases. Degeneration of hepatocells, hemorrhage, and the formation of fibrin-like substances were detected in sections of the liver of the treated dogs stained hematoxylin and eosin and Weigert's staining.

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