DIURNAL RHYTHM OF MELATONIN BINDING IN THE RAT SUPRACHIASMATIC NUCLEUS
- 1 March 1989
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 124 (3) , 1585-1587
- https://doi.org/10.1210/endo-124-3-1585
Abstract
We used quantitative in vitro autoradiography to localize and characterize 2-125I-melatonin binding sites in the rat suprachiasmatic nuclei in relation to pineal melatonin production. In a light:dark cycle of 12:12 h, binding density exhibited significant diurnal variation with a peak at the dark-light transition and a trough 12 hours later. Saturation studies suggested that the decreased binding at light-dark transition might be due to a shift of the putative melatonin receptor to a low affinity state.This publication has 9 references indexed in Scilit:
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