FORMATION OF AN N-ACETYLORNITHINE CONJUGATE OF 3-PHENOXYBENZOIC ACID IN THE CHICKEN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (5) , 523-528
Abstract
The principal metabolite detected in the excreta of chickens treated orally with 3-phenoxybenzoic acid was .alpha.-N-acetyl-.delta.-N-(3-phenoxybenzoyl)-L-ornithine. This conjugate was isolated and purified by preparative HPLC [high-pressure liquid chromatography] and its structure authenticated by mass and NMR spectrometry. Although diacyl ornithine conjugates of aromatic carboxylic acids are formed in some bird species, monosubstituted derivatives are rare. This was the 1st example of the occurrence of an N-acetylornithine conjugate in the biotransformation of a xenobiotic in animals. The conjugation of such nonnutritive acids in avian species was discussed.