Syntheses of tetra‐ and pentapeptides from skin extracts of Phyllomedusa rhodei (tryptophyllins)*
- 1 August 1984
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 24 (2) , 155-160
- https://doi.org/10.1111/j.1399-3011.1984.tb00941.x
Abstract
Syntheses by solution methods of tryptophyllins ‐4 and ‐5 (TPH‐4 and TPH‐5), tetra‐ and pentapeptides isolated from the skin extracts of the South American frog Phyllomedusa rhodei, are reported. The incorporation of the Pro2‐Pro3 sequence into pentapeptides and the use of flash chromatography for purification of intermediates and target compounds are discussed. Preliminary biological results seem to indicate a growth‐promoting activity for this peptide family.Keywords
This publication has 14 references indexed in Scilit:
- Primary structure of tryptophan‐containing peptides from skin extracts of Phyllomedusa rhodei (tryptophyllins)International Journal of Peptide and Protein Research, 1984
- Field desorption mass spectra of dermorphin and some related peptidesBiopolymers, 1983
- TWO NEW FROG SKIN PEPTIDES, PHYLLOLITORINS, OF THE BOMBESIN-RANATENSIN FAMILY FROM Phyllomedusa sauvagei Biomedical Research, 1983
- Chloroform: A Review of Its Metabolism, Teratogenic, Mutagenic, and Carcinogenic PotentialDrug and Chemical Toxicology, 1982
- IDENTIFICATION OF DERMORPHIN AND HYP6‐DERMORPHIN IN SKIN EXTRACTS OF THE BRAZILIAN FROG PHYLLOMEDUSA RHODEIInternational Journal of Peptide and Protein Research, 1981
- AMINO ACID COMPOSITION AND SEQUENCE OF DERMORPHIN, A NOVEL OPIATE‐LIKE PEPTIDE FROM THE SKIN OF PHYLLOMEDUSA SAUVAGEIInternational Journal of Peptide and Protein Research, 1981
- Active polypeptides: from amphibian skin to gastrointestinal tract and brain of mammalsTrends in Pharmacological Sciences, 1980
- Rapid chromatographic technique for preparative separations with moderate resolutionThe Journal of Organic Chemistry, 1978
- Nuclear magnetic resonance evidence for cis-peptide bonds in proline oligomersJournal of the American Chemical Society, 1970
- Synthèse d'analogues structuraux de l'élédoïsine. 1repartie: Préparation des produits intermédiairesHelvetica Chimica Acta, 1963