Hypnotic Action Resulting from Combined Administration of Salicylamide and Acetophenetidin

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Abstract
Ineffective doses of salicylamide (o-hydroxybenzamide) and acetophenetidine (p-ethoxyacetanilide) when given in combination produce hypnosis of considerable duration. An analysis of the synergism between the 2 drugs indicates potentiation when the drugs are given in terms of their median doses causing loss of the righting reflex. When the 2 drugs are given in terms of their median lethal doses an incompletely additive effect is obtained. The ability of related drugs to replace salicylamide or acetophenetidin in the mixtures was also investigated.