IMMUNE RESPONSE TO HETEROLOGOUS RED CELLS IN MICE .2. ANTIBODY FORMATION TO RED CELLS FROM SPECIES TAXONOMICALLY RELATED TO SHEEP OR MOUSE

  • 1 January 1967
    • journal article
    • research article
    • Vol. 13  (6) , 585-+
Abstract
An attempt was made to establish the relative immunogenicity of various heterologous erythrocytes in the mouse. The immune response to multispecies red cells was examined by zone centrifugation of the antibodies, and by studying cross-reactivity between the various erythrocytes, time-course of haemagglutinin formation, and finally, antigen dose-antibody response relationships. As compared to sheep erythrocytes, goat erythrocytes had a greatly reduced agglutinability, which merely simulated a reduced immunogenicity. Erythrocytes from gerbil and hamster proved to be genuinely weaker antigens in the mouse. For alkylating agents, anti-metabolites and anti-mitotic compounds the drug-sensitivty of the immune response to cells of different antigenicity was not altered.