Chronic Virus Infection and Immune Responsiveness

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Abstract
Differences in the immune responsiveness of infected mice against one antigen do not necessarily indicate differences in their total immunologic capacities. Antibodies formed to a variety of antigens in mice infected with lactic dehydrogenase virus (LDV) were compared to those made in uninfected mice. The antigens used were keyhole limpet hemocyanin (KLH), human IgG (HuIgG) and goat red blood cells (GRBC). Against KLH, LDV infected mice made lower immune responses than did uninfected controls, whereas against HuIgG, the immune responses of LDV infected mice were elevated over controls. The formation of antibody to HuIgG was enhanced only soon after primary immunization, was associated with an increased number of direct antibody forming cells in the spleen, and was predominantly of the IgM class. Mice infected with LDV and uninfected mice made similar immune responses to large doses of GRBC, whereas when doses of GRBC were reduced infected mice made lower immune responses.

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