The contribution of tunnelling to high values of kinetic isotope effect in aliphatic hydroxylation by a cytochrome P-450 model
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 1,p. 45-46
- https://doi.org/10.1039/c39900000045
Abstract
High values of kinetic isotope effect (KIE), up to 21.9 ± 1.9 at 20 °C, are obtained in cyclohexane oxidation by an iron tetramesitylporphyrin (TMPFeCl)–hypochlorite system; their very sharp dependence on temperature suggests tunnelling contribution to the C–H bond cleavage step.Keywords
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