Estrogenic and Gonadotrophic Hormone Inhibiting Activity of Some Adrenal Cortical Substances.*

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Abstract
Lipo Adrenal Cortex and desoxycorticosterone acetate stimulated uterine growth and inhibited pituitary gonadotrophic hormone secretion when admd. to female rats in small amts. Adrenal Cortex Extract partially inhibited gonadotrophin secretion but was less than 1/4 as effective as the Lipo Adrenal Cortex. Large doses of Compound E failed to inhibit the gonadotrophin secretion. The secretion of gonadotrophic hormone is inhibited in immature rats by steroids in amts. less than those which result in uterine growth.

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