Concise enantioselective synthesis of a key synthetic intermediate for anticancer anthracyclines based on the chemistry of 1-trimethylsilylbuta-2,3-diene
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1533-1534
- https://doi.org/10.1039/c39910001533
Abstract
(R)-(–)-2-Acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol 6, a key intermediate for the synthesis of anticancer anthracyclines, has been synthesized enantioselectively in 39% overall yield (8 steps) starting from highly diastereoselective reaction of 1-trimethylsilylbuta-2,3-diene with the chiral acetal 7.Keywords
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