THE INTERACTION OF SEA-ANEMONE AND SCORPION NEUROTOXINS WITH TETRODOTOXIN-RESISTANT NA+ CHANNELS IN RAT MYOBLASTS - A COMPARISON WITH NA+ CHANNELS IN OTHER EXCITABLE AND NON-EXCITABLE CELLS
- 1 January 1984
- journal article
- research article
- Vol. 26 (1) , 70-74
Abstract
The properties of interactions of several polypeptide neurotoxins isolated from sea anemone and scorpion venom with Na+ channels of rat myoblasts, chick myotubes, neuroblastoma cells, and fibroblasts were compared. Tetrodotoxin (TTX)-resistant Na+ channels appear to be much more sensitive to the action of sea anemone toxins than TTX-sensitive Na+ channel but have the same affinity for scorpion neurotoxins. This conclusion holds both for Na+ channels that can be activated electrically and for silent forms of Na+ channels. The sensitivity to sea anemone toxins of the different types of Na+ channels that have been studied suggests the existence of multiple forms of Na+ channels.This publication has 2 references indexed in Scilit:
- Tetrodotoxin-sensitive sodium channels in rat muscle cells developing in vitro.Journal of Biological Chemistry, 1983
- Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.Proceedings of the National Academy of Sciences, 1980