Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
Top Cited Papers
- 1 August 2003
- journal article
- research article
- Published by Elsevier in Current Biology
- Vol. 13 (15) , 1259-1268
- https://doi.org/10.1016/s0960-9822(03)00506-2
Abstract
No abstract availableKeywords
Funding Information
- American Cancer Society
- European Molecular Biology Organization
- Human Frontier Science Program
- National Institutes of Health (CA46595, GM41890, GM51405, GM56203)
This publication has 47 references indexed in Scilit:
- Rheb promotes cell growth as a component of the insulin/TOR signalling networkNature Cell Biology, 2003
- Rheb is a direct target of the tuberous sclerosis tumour suppressor proteinsNature Cell Biology, 2003
- Rheb is an essential regulator of S6K in controlling cell growth in DrosophilaNature Cell Biology, 2003
- Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migrationOncogene, 2002
- Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cellsOncogene, 2002
- Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4EGenes & Development, 2002
- Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1Molecular and Cellular Biology, 2001
- Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase PathwayPublished by Elsevier ,2001
- Ras‐effector interactions, the problem of specificityFEBS Letters, 1995
- Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITYJournal of Biological Chemistry, 1995