Acyloxymethyl as a Drug Protecting Group. Part 3. Tertiary O-Amidomethyl Esters of Penicillin G: Chemical Hydrolysis and Anti-Bacterial Activity
- 1 January 1996
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 13 (1) , 70-75
- https://doi.org/10.1023/a:1016077200460
Abstract
Purpose. O-( N-alkylamido)methyl esters of penicillin G were studied as a new class of prodrugs. Methods. Their hydrolysis in aqueous buffers containing 20 % (v/v) of acetonitrile was investigated by...Keywords
This publication has 5 references indexed in Scilit:
- Prodrugs of Peptides. 11. Chemical and Enzymatic Hydrolysis Kinetics of N-Acyloxymethyl Derivatives of a Peptide-like BondPharmaceutical Research, 1991
- Potential Improvement in the Shelf Life of Parenterals Using the Prodrug Approach: Bacampicillin and Talampicillin Hydrolysis Kinetics and Utilization TimePharmaceutical Research, 1988
- PRODRUGS AS DRUG DELIVERY SYSTEMS .74. FACILE HYDROLYSIS OF N-(ACYLOXYMETHYL)AMIDE DERIVATIVES AND IMPLICATIONS FOR THE DESIGN OF PRODRUGS OF NH-ACIDIC COMPOUNDS AND OF CARBOXYLIC-ACIDS1987
- Phenytoin Prodrugs III: Water-Soluble Prodrugs for Oral and/or Parenteral UseJournal of Pharmaceutical Sciences, 1984
- Orally active esters of cephalosporin antibiotics. 3. Synthesis and biological properties of aminoacyloxymethyl esters of 7-[D-(-)-mandelamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acidJournal of Medicinal Chemistry, 1979