Qualitative and Quantitative Determination of Methylsulfone Metabolites of Polychlorinated Biphenyls in Human Milk and Adipose Tissues

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Abstract
Chemical analysis of human milk and adipose tissues obtained from a woman who had been exposed to the polychlorinated biphenyls (PCB) was conducted to study the contamination and metabolites of PCB in a human body.The methylsulfonated PCB (metabolites of PCB) were found in the milk and adipose tissues.Gas chromatograph-mass spectrometric analysis has demonstrated that the methylsulfones of PCB from the human milk were tetra-, penta- and hexa-chlorinated compounds.The concentration of methylsulfones of PCB in the milk and the adipose tissues were estimated to be 0.16-0.79ppm, which corresponded to approximately 1/20 levels of the PCB present in the respective materials.