Short-Term Management of Nesidioblastosis Using the Somatostatin Analogue SMS 201–995

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Abstract
To the Editor: Natural somatostatin has been used to treat children with hyperinsulinemia, but because of the short half-life of the native peptide (two to three minutes), continuous intravenous, subcutaneous infusion must be used.1–4 We report the use of a somatostatin analogue (Sandoz: SMS 201–995) in the short-term care of an infant with nesidioblastosis.A female infant was born by cesarean section at 34 weeks' gestation to a 30-year-old mother with preeclampsia. The birth weight was 2.61 kg (50th percentile). At 14 hours, hypoglycemia (blood glucose <0.1 mmol per liter) was observed, and subsequent investigation revealed nonketotic hypoglycemia with hyperinsulinism . . .

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