ELECTROPHORETIC PATTERN OF RED BLOOD-CELL CATECHOL-O-METHYLTRANSFERASE IN SCHIZOPHRENIA AND MANIC-DEPRESSIVE ILLNESS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 11  (5) , 613-623
Abstract
Human red blood cell (RBC) catechol-O-methyltransferase (COMT) [EC 2.1.1.6] was analyzed by polyacrylamide gel electrophoresis (PAGE). One major enzyme band (B) was observed after electrophoresis. A minor band (A) of COMT activity comprising no more than 25% of the total activity, was also detectable. The rate of migration during electrophoresis of both bands of RBC COMT was the same in manic-depressive, schizophrenic and normal individuals. These results did not reveal genetic variations in the COMT molecule among these 3 groups. When total RBC COMT was measured there were no statistically significant differences between schizophrenic, manic-depressive and control individuals.

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