Factors Affecting the Traffic and Segregation of Lymphoid Cell Populations

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Abstract
Spleen cells from normal (N) or thymus-deprived (B) mice were labelled in vitro with either 3H-adenosine or 3H-5-uridine and injected into syngeneic normal or thymus-deprived mice. The distribution profiles showed that N spleen cells were distributed over both thymus-dependent and thymus-independent (B) compartments of spleen and lymph node, whilst the great majority of B cells were distributed only over B compartments. No difference was observed in the labelling intensity of N or B spleen cells. A quantitative analysis of the number of cells per unit area of T or B areas of lymph nodes demonstrated that lymph nodes in B mice were more receptive to injected cells. Differences between the phenomena of ‘eco-taxis’ and ‘homing’ as applied to migrating lymphoid cells are discussed.