Cerebral decarboxylation ofmeta- andpara-tyrosine

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Abstract
Summary The decarboxylase inhibitor DL-a-monofluoromethyldopa reduces, in a dose dependent manner, the concentration of striatalp-tyramine in the mouse. Homovanillic acid is also significantly reduced. Conversely, this treatment increases them-tyramine concentration. Administration ofm-tyrosine produces large increases inm-tyramine and a slight decrease inp-tyramine; these changes are potentiated in the presence of the decarboxylase inhibitor. Such data along with other recently published results permit the conclusion thatm-tyramine arises from phenylalanine viam-tyrosine and thatp-tyramine arises by decarboxylation ofp-tyrosine. Both these reactions are closely related to the activity of tyrosine hydroxylase and the availability of appropriate substrates.