Delusions and Hallucinations in Frontotemporal Dementia

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Abstract
Frontotemporal dementia (FTD) is associated with marked behavior changes, but hallucinations and delusions are rare. To report a case of FTD with early and persistent delusions, including de Clerambault syndrome. We describe the clinical, neuroradiologic, and neuropathologic findings of a 76-year-old woman with an 11-year course of FTD with bizarre delusions and hallucinations. The patient's autopsy examination of the brain revealed pathology consistent with frontotemporal lobar degeneration with ubiquitin-positive and transactive response (TAR)-DNA-binding protein-43-positive inclusions and hippocampal sclerosis. Delusions and hallucinations can occur in proven frontotemporal pathology.