Regulator Gene Controlling Enzymes Concerned in Tyrosine Biosynthesis in Escherichia coli
- 1 March 1969
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 97 (3) , 1234-41
- https://doi.org/10.1128/jb.97.3.1234-1241.1969
Abstract
Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy- d -arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA , has been designated tyrR .Keywords
This publication has 20 references indexed in Scilit:
- Activation of tyrosine analogs in relation to enzyme repressionBiochemical and Biophysical Research Communications, 1965
- Control of aromatic biosynthesis: The multiplicity of 7-phospho-2-oxo-3-deoxy-d-arabino-heptonate d-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) in Eschetichia coli WBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenaseBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- Optimal conditions for mutagenesis by N-methyl-N′-nitro-N-nitrosoguanidine in escherichia coli K12Biochemical and Biophysical Research Communications, 1965
- The effects of phenylalanine and tyrosine analogs on the synthesis and activity of 3-deoxy-d-arabino-heptulosonic acid 7-phosphate synthetasesArchives of Biochemistry and Biophysics, 1964
- End-product regulation of the general aromatic pathway in Escherichia coliWBiochimica et Biophysica Acta, 1963
- Repression of transaminase by tyrosine in Escherichia coliBiochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1963
- Repression of transaminase by tyrosine in Escherichia coliBiochimica et Biophysica Acta, 1963
- The Synthesis and Properties of D-Erythrose 4-Phosphate1Journal of the American Chemical Society, 1955
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951