In Vivo Studies by Magnetic Resonance Imaging and Spectroscopy of the Response to Tamoxifen of MCF7 Human Breast Cancer Implanted in Nude Mice
- 1 September 1991
- journal article
- research article
- Published by Cognizant, LLC in Cancer Communications
- Vol. 3 (9) , 287-297
- https://doi.org/10.3727/095535491820873001
Abstract
Magnetic resonance 1H-imaging and 31 P-localized spectroscopy were utilized to monitor, noninvasively, MCF7 human breast cancer tumors implanted in immunodeficient mice. The tumors were followed during estrogen dependent growth and tamoxifen induced remission. Early after tamoxifen administration enhanced necrosis developed, extending to most of the tumor volume. This was followed by growth of repair tissue along with tumor regression. The short-term tamoxifen treatment also modified the content of the phosphate metabolites, increasing the nucleoside triphosphate to inorganic phosphate ratio from 0.41 ± 0.15 (n = 14) before treatment to 1.10 ± 0.70 (n = 8, P P No Reference information available - sign in for access. No Citation information available - sign in for access. No Supplementary Data. No Article Media No MetricsKeywords
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