Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig

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Abstract
The effect of furosemide on acid secretion and Cl- transport was studied in isolated fundic mucosa of the guinea pig. Furosemide (10-3 M), applied to the serosal side produced an immediate effect on short-circuit current (Isc) lowering it by 47 .+-. 2%. Potential difference decreased by 29 .+-. 3%, electrical conductance by 18 .+-. 4%, acid secretion by 38 .+-. 1% and net flux of Cl- from serosal-to-mucosal side by 37%. Application of the drug to the mucosal side produced similar effects on acid secretion and on the electrical parameters. Furosemide apparently blocks the entrance of Cl-, by the Na+ - Cl- cotransport mechanism, through the basolateral membrane of the secreting cell. The consequent reduction in electrogenic Cl- transport would cause Isc and acid secretion to decrease. A reduction of Cl- conductance of the apical membrane, upon mucosal application of the drug, caused similar effects on acid secretion and Cl- transport.

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