Identification of Strychnine Binding Sites in the Rat Retina
- 1 April 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (4) , 1597-1600
- https://doi.org/10.1111/j.1471-4159.1981.tb00606.x
Abstract
[3H]Strychnine specifically binds to membrane fractions isolated from rat retinae. The binding is saturable, with an apparent dissociation constant, KD, of 14.3 × 10−9 M and 205 fmol bound/mg protein. Specific binding is time‐dependent and proportional to protein concentration. Glycine and taurine are equally potent inhibitors of [3H]strychnine binding (Ki= 4 × 10−5 M); no other amino acids endogenously present in the retina inhibited [3H]strychnine binding.Keywords
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