Derivation of Lymphoma Variants With Reduced Sensitivity to Plant Lectins2

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Abstract
Variant murine lymphoma cell lines no longer sensitive to the cytotoxic action of lectin antilectin and complement were selected. Lectins were affinity-purified Ricinus communis and wheat germ agglutinins. The variant cell lines expressed 0.5–0.7 of the parental amount of total lectin-binding sites and showed a 10- to 100-fold decrease in sensitivity to the direct cytotoxic action of the lectin. There were no significant changes in other cellsurface determinants.