RELATION OF MUSCULAR FATIGUE IN THE ADRENALECTOMIZED DOG TO INADEQUATE CIRCULATORY ADJUSTMENT

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Abstract
Simultaneous work performance (gastrocnemius muscle) and blood pressure studies were made in normal and desoxycorticosterone (DOC)-treated adrenalectomized dogs. Normal dogs maintained work performance and blood pressure for 12 hrs. of continuous stimulation, at their initial levels. Adrenalectomized dogs maintained normal work performance and blood pressure only j for a short time. Within 1-4 hrs. a progressive and finally fatal fall in blood pressure occurred. The blood pressure fall preceded the signs of muscular fatigue in all cases. The failing work performance of adrenalectomized animals is a result of circulatory maladjustment to the demands of work. The concept of a maladaptation of the neuro-circulatory systems of regulation due to C-11 oxysteroid lack is discussed in relation to muscle fatigue, and to the general sensitivity of the adrenalectomized animal to stress.

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