COAGULATION STUDIES IN THE NEWBORN INFANT

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Abstract
Determinations of the whole blood clotting time, prothrombin concentration, protamine titration, platelet count, and clot lysis were done on 10 infants with erythroblastosis fetalis on the first, third and fifth days of life. On the first day of life the average whole blood clotting time was 27 minutes as compared to an average of 14 minutes in the normal infant. The protamine titration was increased beyond normal adult values in 60% of the infants as compared with 23% of normal infants. The prothrombin concentration was comparable to that of the normal infant. Eight of these infants received replacement transfusions and repeat determinations of the above factors immediately after transfusion showed a return to normal of the protamine titration. Heparin sensitivity tests done on three of the treated infants before and after transfusion were essentially normal. On the third day of life the average whole blood clotting time was 10½ minutes in the treated infants as contrasted with 25 minutes in the normal infant. Protamine titrations were normal in all infants. The average prothrombin concentration was 77% as compared with 65% in the normal three day infant. On the fifth day of life all determinations were normal except for those from three infants who had increased protamine titrations.

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