OCULAR PATHOLOGY INDUCED BY SUCKLING MOUSE CATARACT AGENT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (8) , 640-647
Abstract
The eye disease caused by SMCA [suckling mouse cataract agent (Spiroplasma)] may be best characterized [in mice] as an endophthalmitis, with early retinitis followed by subsequent posterior uveitis. Pathologic features of lens include proliferation and abnormal posterior extention of lens epithelium, increased accumulation of lens capsule material and production of aberrant lens substance. Cataractous change appears to be secondary to intraocular inflammation. In addition to the above pattern, in roughly 20% of all cases, 3 wk after inoculation, lens capsule is destroyed giving rise to a foreign body granulomatous reaction.

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