[The predominant expression of Th2 type cytokines in human tumor cells].

  • 1 March 1998
    • journal article
    • abstracts
    • Vol. 20  (2) , 105-7
Abstract
To observe the expression of Th1 versus Th2 type cytokines in human tumor cells. The gene expression of Th1/Th2 cytokines in human tumor cells was detected by RT-PCR and RNA dot hybridization using IL-2 and IFN gamma as Th1 type cytokine genes, IL-4, IL-10 and IL-13 as Th2 type cytokine genes. There were predominant expressions of Th2 type cytokines in 20 different human tumor cell lines including 11 solid tumor and 9 hematogenous tumor cells. Predominant expression of Th2 type cytokines by tumor cells may be related to the evasion of tumor cells from immune surveillance.

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